Pure Protein, LLC.

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Pure Protein, L.L.C. is a biotechnology company focused on the development and commercialization of proprietary technologies related to the human leukocyte antigen (HLA) system, exclusively licensed from the University of Oklahoma. Pure Protein, in conjunction with its affiliates and subsidiaries, aims to bring novel therapies and diagnostic tools to patients across a wide range of application areas spanning from therapeutic development in the fields of oncology, autoimmunity, and infectious disease, to antibody mediated rejection in transplantation.

Pure Protein is proud to announce the launch of its new website www.hlaprotein.com to offer researchers naturally folded and endogenously loaded soluble HLA proteins and improved vaccination and therapeutic targeting strategies through its HLA peptide epitope binding services to validate, screen, or map immune targets.

About Us

Founded in 1999, Pure Protein is a portfolio company of leading life sciences technology management firm Emergent Technologies, Inc. Pure Protein’s business operations are based in Austin, TX with research & development and production facilities in Oklahoma City, OK.

Pure Protein addresses the commercial and research need for supply of single specificity, glycosylated HLA proteins. The company was founded on the unique and proprietary technologies developed by Chief Scientists Dr. William Hildebrand at the University of Oklahoma Health Sciences Center.

Technology

Pure Protein has pioneered an approach to produce soluble forms of HLA Class I and Class II proteins (sHLA). Only Pure Protein can make significant quantities of this highly purified and naturally processed product. These endogenously loaded, naturally glycosylated proteins can be used for critical research and in the development of diagnostics and therapeutics needed for a variety of immunotherapy applications.

Pure Protein’s sHLA proteins provide superior scale, yield, and purity over other products. The genetic compositions, production methods, and uses, including antibody removal, antibody detection, and target discovery are protected by a series of issued and pending patents. In addition to patents, Pure Protein has developed a comprehensive suite of proprietary know-how and expertise over its years of HLA research.

Pure Protein’s sHLA are naturally glycosylated and loaded with the full repertoire of endogenous peptide ligands, unlike HLA production using bacterial and insect systems. Because Pure Protein synthesizes HLA proteins in mammalian cells rather than insect or bacterial cells, Pure Protein’s sHLA circumvent the purification and production issues afflicting competing technologies. After over twenty years of research, Pure Protein has developed hundreds of Class I and Class II sHLA proteins representing all major classes A, B, C, DR, DQ, DP.

Products and Applications

sHLA Proteins – Pure Protein has developed hundreds of Class I and Class II single specificity, glycosolated HLA proteins suitable for a wide variety of diagnostic and therapeutic applications. To purchase proteins or to learn more about Pure Protein’s service offerings, please visit:. www.hlaprotein.com

Target Discovery Applications – Pure Protein’s sister company Pure MHC, LLC is a platform technology company with expertise in disease-specific target identification and validation as well as immunotherapeutic drug development for cancer, infectious, autoimmune diseases and allergy. To learn more visit: www.puremhc.com.
Transplantation Therapeutics and Diagnostics – Pure Transplant Solutions, LLC. is a Pure Protein subsidiary, founded to develop the core HLA technologies into solutions that address a growing list of needs in organ transplantation. For more information please visit the
Pure Transplant Solutions website.
Collaborations - Pure Protein and its subsidiaries are collaboration driven. Click here to learn more about our current collaborations. For partnership inquiries, please contact us..

News

July 21, 2021 - Pure Transplant Solutions, LLC Announces Research Collaboration with the Department of Surgery at the University of Cambridge

March 31, 2021 - Pure MHC, LLC Announces Launch of Contract Research Service Division and Initial Collaboration Project with argenx

March 24, 2021 - Pure Transplant Solutions Announces Collaboration with Innobiochips to Develop Personalized Diagnostics for Post-Transplant Monitoring and Early Detection of Transplant Rejection

March 17, 2021 - Pure Transplant Solutions Announces Collaboration with Northwestern University to Develop Novel Reagents for Enhanced Characterization of HLA DQ Antigens In Transplant Rejection

March 16, 2021 - Pure MHC, LLC Announces Launch of its Peptide HLA Immunotherapy Data Resource following Collaboration with LifeNet Health

March 11, 2021 - Pure Transplant Solutions Announces Collaboration with the University of Alabama at Birmingham to Develop Memory B Cell-Directed Diagnostics for HLA-Sensitized Patients

February 24, 2021 - Pure Transplant Solutions Announces Collaboration with King’s College London to Support NHS Funded GAMECHANgER-1 Clinical Trial for HLA Sensitized Patients with End Stage Renal Disease

February 4, 2021 - Pure Protein, LLC and Pure Transplant Solutions, LLC Promote Blake Harlan to President and Dr. Rico Buchli to Vice President of Products and Service

January 27, 2021 - Pure Transplant Solutions, LLC and University Hospital Basel Announce Research Collaboration Developing New Diagnostics for Donor Specific Antibodies (DSA) in Transplant Rejection

November 30, 2020 - Pure Protein, LLC Announces New Website Launch Now Offering Its HLA Reagents and Technical Services to Researchers

October 15, 2020 - Pure Protein, LLC to Exhibit and Preview New Website at the American Society for Histocompatibility and Immunogenetics (ASHI) 46th Annual Meeting

March 20, 2020 - OU Health Sciences Center Partners With Pure MHC on COVID-19 Vaccine Project

February 13, 2019 - Emergent Technologies, Inc. Hires Steven Lloyd Mayer, MD as Chief Medical Officer and Promotes Blake Harlan to Executive Vice President Finance and Operations

January 9, 2017 - Pure MHC to Partner with AbbVie on Oncology Research

Contact Us

Managed by Emergent Technologies, Inc.


Research Facilities
Pure Protein, LLC
655 Research Parkway, Suite 525
Oklahoma City, Oklahoma 73104

Phone: (405) 271-3838
Email: info@pureproteinllc.com

Mailing Address
Emergent Technologies, Inc.
1105 Castle Court
Austin, TX 78703
Phone: (512) 263-3232
Email: info@etibio.com

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