Pure Protein, LLC.

Pure Protein has pioneered an approach to produce soluble forms of HLA Class I and Class II proteins (sHLA). Only Pure Protein can make significant quantities of this highly purified and naturally processed product. These endogenously loaded, naturally glycosylated proteins can be used for critical research and in the development of diagnostics and therapeutics needed for a variety of immunotherapy applications.

Pure Protein’s sHLA proteins provide superior scale, yield, and purity over other products. The genetic compositions, production methods, and uses, including antibody removal, antibody detection, and target discovery are protected by a series of issued and pending patents. In addition to patents, Pure Protein has developed a comprehensive suite of proprietary know-how and expertise over its years of HLA research.

Pure Protein’s sHLA are naturally glycosylated and loaded with the full repertoire of endogenous peptide ligands, unlike HLA production using bacterial and insect systems. Because Pure Protein synthesizes HLA proteins in mammalian cells rather than insect or bacterial cells, Pure Protein’s sHLA circumvent the purification and production issues afflicting competing technologies. After over twenty years of research, Pure Protein has developed hundreds of Class I and Class II sHLA proteins representing all major classes A, B, C, DR, DQ, DP.