Detecting and counteracting false alarms in the immune system.
HLA proteins act as an alarm system for cancerous and infected cells, with T-Cells being the first responders. When T-Cells recognize and bind to a foreign HLA epitope, they trigger the alarm and produce antibodies. This in turn amplifies the response to the diseased cells presenting the foreign HLA epitope. Similar to infections, responses to foreign HLA can be triggered when a person is exposed to these HLA alleles through transplants, child birth, or transfusion. This can cause the cascade effect that produces antibodies directed against foreign HLA, leading to rejection. Utilizing proprietary technology, Pure Protein is working with industry partners to develop screening tests to prevent the rejection of organs in the growing field of organ transplant matching.