Current research programs include:
- Factors that Influence Consistency in HLA Single Antigen Assays
- Soluble HLA Stress Testing of HLA Proteins on Single Antigen Beads
- Derivation and Testing HLA Monospecific Antibodies Identification of Agreeable Reagents
- Deconvolution of Anti-HLA Sera Using Soluble HLA-Linked Matrices
Antibodies to HLA proteins are found in the blood supply. A blood recipient can suffer and die from transfusion related acute lung injury (TRALI) when antibodies to HLA in the blood they receive causes their lungs to fail. It is therefore likely that the blood supply will be screened for antibodies to HLA. Pure is working with the blood banking industry to develop an assay that will detect antibodies to HLA in donated blood.
Hildebrand Research in conjunction with Pure
Some HLA proteins are monomorphic meaning we all have the same version of that HLA type. Tb is hard to diagnose and hard to treat. In order to develop the next generation of Tb diagnostics and therapies, Pure is working to identify Tb epitopes that are presented by monomorphic HLA.
Rhesus macaque and Cynomolgus macaque
We provide the Non-human primate (NHP) research community with information on how these monkeys MHC function and present peptides with a view toward finding macaque MHCs that are homologues of human MHC proteins.
Lipid presenting HLAs
There are another class of monomorphic MHCs, known as CD1,that present lipids instead of peptides. CD1 tell you what membranes (lipids) are being assembled in the cells at that time. Pure studies these to see what kinds of lipids characterize a disease state from a normal state.
Using the Pure Epitope Discovery Platform, we are asking the question: How are ovarian cancer cells are different from normal cells in terms of their HLA tags? The epitopes that distinguish cancerous cells in ovaries can be incorporated into with high confidence into a vaccine. This research is in early stage discovery.
This is a project to determine how the HLA of HIV cells differs from the HLA of non-infected cells. The purpose is to see if an HIV vaccine can be designed A Fulbright Scholar from Indonesia where HIV is a particular health concern, conducts this work in the Hildebrand lab.
Autoimmune Disease Research
Pure's initial forays into the application of its technology to the understanding and control of autoimmune diseases has not been focused on one specific autoimmune disease, but rather on the creation of HLAs with built-in regulatory functions that can affect numerous autioimmune responses at a fundamental level.
Other specific autoimmune diseases of interest are Rheumatoid arthritis, Lupus, and MS.